![]() Preclinical studies have shown potential antidepressant effects of orexin antagonists, which are used to treat insomnia. Trazodone, the most commonly used antidepressant, reduces the number of awakenings. Low-dose doxepin improves sleep continuity and is FDA approved for the treatment of chronic insomnia. TCA drugs can be sedating or stimulating. SSRI, SNRI, and TCA drugs reduce REM sleep and increase REM latency. Recent Findings: Antidepressants remain commonly used off-label for the treatment of chronic insomnia. N2 - Purpose of Review: Given the strong bidirectional relationship between sleep disruption and psychiatric conditions, particularly between depression and insomnia, it is important to understand the beneficial and potentially harmful effects of antidepressants on sleep. T1 - Antidepressants and Their Impact on Sleep Orexin antagonists may represent a future approach for treatment of both depression and insomnia.", Low-dose doxepin is the only FDA-approved antidepressant for insomnia. Summary: Data on the usage of most antidepressants for insomnia remain limited. Orexin antagonists may represent a future approach for treatment of both depression and insomnia.Ībstract = "Purpose of Review: Given the strong bidirectional relationship between sleep disruption and psychiatric conditions, particularly between depression and insomnia, it is important to understand the beneficial and potentially harmful effects of antidepressants on sleep. ![]() ![]() Purpose of Review: Given the strong bidirectional relationship between sleep disruption and psychiatric conditions, particularly between depression and insomnia, it is important to understand the beneficial and potentially harmful effects of antidepressants on sleep. ![]()
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